Histone variants: essential actors in male genome programming
نویسندگان
چکیده
منابع مشابه
I-40: Male Genome Programming, Infertility and Cancer
Background: During male germ cells differentiation, genomewide re-organizations and highly specific programming of the male genome occur. These changes not only include the large-scale meiotic shuffling of genes, taking place in spermatocytes, but also a complete “re-packaging” of the male genome in post meiotic cells, leading to a highly compacted nucleo-protamine structure in the mature sperm...
متن کاملOrganizing the genome with H2A histone variants.
Chromatin acts as an organizer and indexer of genomic DNA and is a highly dynamic and regulated structure with properties directly related to its constituent parts. Histone variants are abundant components of chromatin that replace canonical histones in a subset of nucleosomes, thereby altering nucleosomal characteristics. The present review focuses on the H2A variant histones, summarizing curr...
متن کاملProgramming with Actors in Java 8
There exist numerous languages and frameworks that support an implementation of a variety of actor-based programming models in Java using concurrency utilities and threads. Java 8 is released with fundamental new features: lambda expressions and further dynamic invocation support. We show in this paper that such features in Java 8 allow for a high-level actor-based methodology for programming d...
متن کاملProteomic strategy for the identification of critical actors in reorganization of the post-meiotic male genome.
After meiosis, during the final stages of spermatogenesis, the haploid male genome undergoes major structural changes, resulting in a shift from a nucleosome-based genome organization to the sperm-specific, highly compacted nucleoprotamine structure. Recent data support the idea that region-specific programming of the haploid male genome is of high importance for the post-fertilization events a...
متن کاملHistone variants and epigenetics.
Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin differentiation. Alternative mechanisms for depositin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Biochemistry
سال: 2017
ISSN: 0021-924X,1756-2651
DOI: 10.1093/jb/mvx079